Release Notes for Pumas 2.3.1
Pumas
Bug fixes and minor improvements
- Changed
EVID
toevid
in aread_pumas
error message to clearly communicate that the keyword is lower case - Fixed the VPC error messages when nodes argument is invalid.
- Reenable the
fit
docstrings that were removed by mistake in v2.3.0 - Fixed the feature of using colon-definitions in
@init
block to allow for calculations that do not directly set an initial value of a compartment - Fixed some language issues in show method for
FittedPumasModelInspection
NCA
Bug fixes and minor improvements
- Fixed a bug in NCA where the percentage of AUC that comes from the extrapolated part of the curve would use non-existent keyword argument internally.
Bioequivalence
Features
- Statistical significance now uses Satterthwaite degrees of freedom
- Support for additional replicated designs
- Results include estimates of within-subject variability CV
- Adapted the reference scaling from the ABEL framework to using the critical boundary re-specification according to latest regulatory guidance.
- Reference scaling parameter changed from regulatory and auxiliary parameters to (
theta
- regulatory parameter) andcv_max
for maximum within-subject variability for expanding the confidence interval. - Model estimation for linear mixed models in replicated designs now use the repeated observation structure per regulatory guidance.
Bug fixes and minor improvements
- Column mapping arguments now accept
AbstractString
andInteger
in addition toSymbol
arguments.