Dosing Control Parameters (DCP)

Dosing Control Parameters (DCP)

The pre part of a PumasModel allows for specifying special preprocessed parameters known as the Dosing Control Parameters (DCP). Unlike standard parameters which are for use in the proceeding blocks, the DCP are used to modify the internal event handling of the Pumas. The DCP are defined as follows:

rate and duration handling are intertwined and always satisfy the relation amt = rate*duration. Any two of the values are given, the third is automatically defined. If both rate and duration are specified, then an error will be given unless amt = rate*duration is satisfied.

Input Definition

If a DCP is defined as a scalar, then it applies to all doses. For example, if a pre block contains the definition:

lags = θ

and θ is a scalar, then every dose will be lagged by the parameter θ. Likewise, if a DCP is defined as a collection, then the value of the collection corresponding to the cmt of the dose specifies the DCP. For example:

lags = [2,0]

implies that any dose into cmt=1 will have a lag of 2, while any dose into cmt=2 will have a lag of 0.

Note: the ability to specify a DCP by a NamedTuple with names matching the dynamical parameters is in development